Etoposide (VP-16): Harnessing DNA Topoisomerase II Inhibi...

2025-10-18

Etoposide (VP-16) represents more than a cornerstone cytotoxic agent; it is now a strategic catalyst at the nexus of DNA damage, genome integrity, and translational oncology. This thought-leadership article unifies emerging mechanistic insights—including the interplay between DNA double-strand breaks, apoptosis induction, and the nuclear cGAS axis—with actionable guidance for researchers seeking to bridge fundamental discovery and clinical innovation. By contextualizing Etoposide’s role within advanced experimental frameworks and referencing recent landmark findings, we empower next-generation cancer researchers to design transformative studies that go far beyond traditional applications.